Supplement Catalog

Explore supplements commonly mentioned in longevity protocols. Each entry includes typical dosing, timing, and important interaction warnings.

CoQ10 (Ubiquinol)
Coenzyme Q10 is a naturally occurring compound that plays a vital role in cellular energy production and acts as a powerful antioxidant. Ubiquinol is the active, reduced form of CoQ10 that is better absorbed than conventional CoQ10 supplements. It supports heart health, may help reduce migraine frequency, and can help counteract the natural decline in CoQ10 levels that occurs with aging.
Typical Dosage
100-300mg daily of ubiquinol form
When to Take
With meals containing fat for optimal absorption, as CoQ10 is fat-soluble
Why for 50+
After age 40, natural CoQ10 production begins to decline significantly, and by age 65, levels can be 50% lower than in younger adults. Adults over 50 also have reduced ability to convert standard CoQ10 to the active ubiquinol form, making ubiquinol supplementation particularly beneficial. This is especially important for those taking statin medications, which further deplete CoQ10 levels.
Potential Interactions
Blood thinners (warfarin) - may reduce effectiveness of anticoagulation
Chemotherapy drugs - may interfere with treatment effectiveness
Antihypertensive medications (blood pressure medications) - may enhance blood pressure lowering effects
Antidepressants - potential interaction with certain classes
Statin medications - while often taken together to counteract statin-induced CoQ10 depletion, monitoring recommended
Curcumin/Turmeric
Curcumin is the active compound in turmeric, a golden spice with potent anti-inflammatory properties. Research suggests it may help reduce joint pain, support heart health, and assist with blood sugar management. Enhanced formulations with improved absorption are recommended since curcumin has naturally poor bioavailability.
Typical Dosage
500-1,500mg curcumin extract daily (equivalent to 500mg-2g turmeric extract)
When to Take
With meals containing fat to enhance absorption, or as directed on enhanced bioavailability formulations
Why for 50+
Adults over 50 often experience increased inflammation and joint discomfort, making curcumin's anti-inflammatory properties particularly valuable. Age-related changes in metabolism may also benefit from curcumin's support for blood sugar regulation and cardiovascular health. However, older adults are more likely to be taking medications that interact with curcumin, making medical consultation essential.
Potential Interactions
Blood thinners (warfarin, aspirin) - may increase bleeding risk
Diabetes medications (metformin) - may enhance blood sugar lowering effects
Blood pressure medications - may potentiate hypotensive effects
Chemotherapy drugs - may interfere with cancer treatment effectiveness
Iron supplements - may reduce iron absorption
Gallstone medications - may worsen gallbladder conditions
View on Amazon(opens in new tab)
Affiliate link
NMN (Nicotinamide Mononucleotide)
NMN is a naturally occurring compound that serves as a precursor to NAD+, a crucial molecule for cellular energy production and DNA repair. Research suggests it may support healthy aging by improving muscle function, insulin sensitivity, and cardiovascular health. While promising, human clinical trials are still limited and more research is needed to confirm long-term benefits.
Typical Dosage
250-500mg daily (based on clinical studies showing safety up to 500mg single dose)
When to Take
Take with food, preferably with fatty foods if combining with other supplements like resveratrol
Why for 50+
As we age, our natural NAD+ levels decline significantly, which can impact cellular energy production and DNA repair mechanisms. Adults over 50 may particularly benefit from NMN supplementation as clinical studies have shown improvements in muscle strength, walking distance, and insulin sensitivity in middle-aged and older adults. The age-related decline in NAD+ makes supplementation potentially more beneficial for this population than younger individuals.
Recommended by
AH
Andrew Huberman
Potential Interactions
Blood pressure medications (may enhance hypotensive effects)
Diabetes medications (may affect blood sugar levels due to insulin sensitivity improvements)
Anticoagulants and blood thinners (theoretical interaction due to cardiovascular effects)
Cholesterol-lowering medications (may interact with lipid metabolism pathways)
Generally well-tolerated with minimal documented interactions in current studies
Resveratrol
Resveratrol is a polyphenolic compound naturally found in red wine, grapes, and berries that acts as a powerful antioxidant in the body. Research suggests it may support cardiovascular health, cognitive function, and healthy aging through its anti-inflammatory properties. Clinical studies have shown potential benefits for blood sugar control, weight management, and brain health, though more long-term research is needed.
Typical Dosage
150-500mg daily (clinical studies have safely used up to 1,000mg daily)
When to Take
With fatty foods in the morning to enhance absorption and support natural circadian rhythms
Why for 50+
Adults over 50 may particularly benefit from resveratrol's cardiovascular and cognitive support properties, as these systems naturally decline with age. The compound's potential to support healthy blood sugar levels and reduce inflammation becomes increasingly important as metabolic function changes with aging. Additionally, emerging research suggests resveratrol may help protect against age-related cognitive decline and support overall healthspan.
Potential Interactions
Blood thinners (warfarin, clopidogrel) - may increase bleeding risk
Blood pressure medications - may enhance blood pressure lowering effects
Cancer treatments - may interfere with certain chemotherapy drugs
MAOI antidepressants - potential interaction with monoamine oxidase inhibitors
NSAID pain relievers - may increase risk of bleeding when combined
Antiviral and antifungal medications - may affect drug metabolism
CYP3A4 metabolized drugs - resveratrol inhibits this enzyme, potentially increasing drug levels
Vitamin B12 (Cyanocobalamin/Methylcobalamin)
Vitamin B12 is an essential water-soluble vitamin that maintains healthy nerve cells, supports red blood cell formation, and aids in DNA synthesis. It plays a crucial role in brain function, energy metabolism, and preventing megaloblastic anemia. This vitamin is particularly important for neurological health and cognitive function as we age.
Typical Dosage
2.4 mcg daily (RDA) for maintenance; 500-1000 mcg daily for correcting deficiency; up to 2000 mcg for seniors with absorption issues
When to Take
Can be taken with or without food; morning preferred to avoid potential sleep interference; sublingual forms may be held under tongue for 30 seconds
Why for 50+
Adults over 50 have significantly reduced stomach acid production, which impairs the body's ability to extract B12 from food sources. Additionally, the prevalence of B12 deficiency increases dramatically with age, affecting 10-15% of adults over 60. Many seniors take medications like proton pump inhibitors or metformin that further reduce B12 absorption, making supplementation particularly important for maintaining cognitive function and preventing neuropathy.
Recommended by
JF
Joel Fuhrman
Potential Interactions
Metformin (diabetes medication) - can reduce B12 absorption with long-term use
Proton pump inhibitors (omeprazole, lansoprazole) - reduce stomach acid needed for B12 absorption
H2 receptor antagonists (ranitidine, famotidine) - may decrease B12 absorption
Colchicine (gout medication) - can impair B12 absorption
Chloramphenicol (antibiotic) - may reduce effectiveness of B12 supplementation
Vitamin D3 + K2 (Cholecalciferol + Menaquinone)
A synergistic combination of vitamin D3 and vitamin K2 that works together to optimize calcium metabolism in the body. Vitamin D3 enhances calcium absorption from the digestive tract, while vitamin K2 activates proteins that direct calcium to bones and teeth while preventing its accumulation in arteries. This partnership supports both bone health and cardiovascular protection.
Typical Dosage
1000-4000 IU vitamin D3 with 45-180 mcg vitamin K2 daily (commonly 1000 IU D3 with 45-100 mcg K2)
When to Take
With meals containing fat for optimal absorption of both fat-soluble vitamins
Why for 50+
Adults over 50 experience decreased vitamin D production in the skin and reduced calcium absorption efficiency. Age-related changes in kidney function also affect vitamin D activation, while declining bone density increases the need for proper calcium utilization. The D3+K2 combination becomes particularly important as cardiovascular calcification risks increase with age.
Recommended by
DS
David Sinclair
Potential Interactions
Warfarin and other blood-thinning medications (vitamin K2 can affect blood clotting)
Antiplatelet drugs like clopidogrel (potential bleeding risk alterations)
Thiazide diuretics (may increase calcium levels when combined with vitamin D3)
Calcium channel blockers (vitamin D3 may affect calcium balance)
Digoxin (vitamin D3 can increase calcium levels, potentially affecting heart rhythm)

CoQ10 (Ubiquinol)
Coenzyme Q10 is a naturally occurring compound that plays a vital role in cellular energy production and acts as a powerful antioxidant. Ubiquinol is the active, reduced form of CoQ10 that is better absorbed than conventional CoQ10 supplements. It supports heart health, may help reduce migraine frequency, and can help counteract the natural decline in CoQ10 levels that occurs with aging.
Typical Dosage
100-300mg daily of ubiquinol form
When to Take
With meals containing fat for optimal absorption, as CoQ10 is fat-soluble
Why for 50+
After age 40, natural CoQ10 production begins to decline significantly, and by age 65, levels can be 50% lower than in younger adults. Adults over 50 also have reduced ability to convert standard CoQ10 to the active ubiquinol form, making ubiquinol supplementation particularly beneficial. This is especially important for those taking statin medications, which further deplete CoQ10 levels.
Potential Interactions
Blood thinners (warfarin) - may reduce effectiveness of anticoagulation
Chemotherapy drugs - may interfere with treatment effectiveness
Antihypertensive medications (blood pressure medications) - may enhance blood pressure lowering effects
Antidepressants - potential interaction with certain classes
Statin medications - while often taken together to counteract statin-induced CoQ10 depletion, monitoring recommended
Curcumin/Turmeric
Curcumin is the active compound in turmeric, a golden spice with potent anti-inflammatory properties. Research suggests it may help reduce joint pain, support heart health, and assist with blood sugar management. Enhanced formulations with improved absorption are recommended since curcumin has naturally poor bioavailability.
Typical Dosage
500-1,500mg curcumin extract daily (equivalent to 500mg-2g turmeric extract)
When to Take
With meals containing fat to enhance absorption, or as directed on enhanced bioavailability formulations
Why for 50+
Adults over 50 often experience increased inflammation and joint discomfort, making curcumin's anti-inflammatory properties particularly valuable. Age-related changes in metabolism may also benefit from curcumin's support for blood sugar regulation and cardiovascular health. However, older adults are more likely to be taking medications that interact with curcumin, making medical consultation essential.
Potential Interactions
Blood thinners (warfarin, aspirin) - may increase bleeding risk
Diabetes medications (metformin) - may enhance blood sugar lowering effects
Blood pressure medications - may potentiate hypotensive effects
Chemotherapy drugs - may interfere with cancer treatment effectiveness
Iron supplements - may reduce iron absorption
Gallstone medications - may worsen gallbladder conditions
View on Amazon(opens in new tab)
Affiliate link
NMN (Nicotinamide Mononucleotide)
NMN is a naturally occurring compound that serves as a precursor to NAD+, a crucial molecule for cellular energy production and DNA repair. Research suggests it may support healthy aging by improving muscle function, insulin sensitivity, and cardiovascular health. While promising, human clinical trials are still limited and more research is needed to confirm long-term benefits.
Typical Dosage
250-500mg daily (based on clinical studies showing safety up to 500mg single dose)
When to Take
Take with food, preferably with fatty foods if combining with other supplements like resveratrol
Why for 50+
As we age, our natural NAD+ levels decline significantly, which can impact cellular energy production and DNA repair mechanisms. Adults over 50 may particularly benefit from NMN supplementation as clinical studies have shown improvements in muscle strength, walking distance, and insulin sensitivity in middle-aged and older adults. The age-related decline in NAD+ makes supplementation potentially more beneficial for this population than younger individuals.
Recommended by
AH
Andrew Huberman
Potential Interactions
Blood pressure medications (may enhance hypotensive effects)
Diabetes medications (may affect blood sugar levels due to insulin sensitivity improvements)
Anticoagulants and blood thinners (theoretical interaction due to cardiovascular effects)
Cholesterol-lowering medications (may interact with lipid metabolism pathways)
Generally well-tolerated with minimal documented interactions in current studies
Resveratrol
Resveratrol is a polyphenolic compound naturally found in red wine, grapes, and berries that acts as a powerful antioxidant in the body. Research suggests it may support cardiovascular health, cognitive function, and healthy aging through its anti-inflammatory properties. Clinical studies have shown potential benefits for blood sugar control, weight management, and brain health, though more long-term research is needed.
Typical Dosage
150-500mg daily (clinical studies have safely used up to 1,000mg daily)
When to Take
With fatty foods in the morning to enhance absorption and support natural circadian rhythms
Why for 50+
Adults over 50 may particularly benefit from resveratrol's cardiovascular and cognitive support properties, as these systems naturally decline with age. The compound's potential to support healthy blood sugar levels and reduce inflammation becomes increasingly important as metabolic function changes with aging. Additionally, emerging research suggests resveratrol may help protect against age-related cognitive decline and support overall healthspan.
Potential Interactions
Blood thinners (warfarin, clopidogrel) - may increase bleeding risk
Blood pressure medications - may enhance blood pressure lowering effects
Cancer treatments - may interfere with certain chemotherapy drugs
MAOI antidepressants - potential interaction with monoamine oxidase inhibitors
NSAID pain relievers - may increase risk of bleeding when combined
Antiviral and antifungal medications - may affect drug metabolism
CYP3A4 metabolized drugs - resveratrol inhibits this enzyme, potentially increasing drug levels
Vitamin B12 (Cyanocobalamin/Methylcobalamin)
Vitamin B12 is an essential water-soluble vitamin that maintains healthy nerve cells, supports red blood cell formation, and aids in DNA synthesis. It plays a crucial role in brain function, energy metabolism, and preventing megaloblastic anemia. This vitamin is particularly important for neurological health and cognitive function as we age.
Typical Dosage
2.4 mcg daily (RDA) for maintenance; 500-1000 mcg daily for correcting deficiency; up to 2000 mcg for seniors with absorption issues
When to Take
Can be taken with or without food; morning preferred to avoid potential sleep interference; sublingual forms may be held under tongue for 30 seconds
Why for 50+
Adults over 50 have significantly reduced stomach acid production, which impairs the body's ability to extract B12 from food sources. Additionally, the prevalence of B12 deficiency increases dramatically with age, affecting 10-15% of adults over 60. Many seniors take medications like proton pump inhibitors or metformin that further reduce B12 absorption, making supplementation particularly important for maintaining cognitive function and preventing neuropathy.
Recommended by
JF
Joel Fuhrman
Potential Interactions
Metformin (diabetes medication) - can reduce B12 absorption with long-term use
Proton pump inhibitors (omeprazole, lansoprazole) - reduce stomach acid needed for B12 absorption
H2 receptor antagonists (ranitidine, famotidine) - may decrease B12 absorption
Colchicine (gout medication) - can impair B12 absorption
Chloramphenicol (antibiotic) - may reduce effectiveness of B12 supplementation
Vitamin D3 + K2 (Cholecalciferol + Menaquinone)
A synergistic combination of vitamin D3 and vitamin K2 that works together to optimize calcium metabolism in the body. Vitamin D3 enhances calcium absorption from the digestive tract, while vitamin K2 activates proteins that direct calcium to bones and teeth while preventing its accumulation in arteries. This partnership supports both bone health and cardiovascular protection.
Typical Dosage
1000-4000 IU vitamin D3 with 45-180 mcg vitamin K2 daily (commonly 1000 IU D3 with 45-100 mcg K2)
When to Take
With meals containing fat for optimal absorption of both fat-soluble vitamins
Why for 50+
Adults over 50 experience decreased vitamin D production in the skin and reduced calcium absorption efficiency. Age-related changes in kidney function also affect vitamin D activation, while declining bone density increases the need for proper calcium utilization. The D3+K2 combination becomes particularly important as cardiovascular calcification risks increase with age.
Recommended by
DS
David Sinclair
Potential Interactions
Warfarin and other blood-thinning medications (vitamin K2 can affect blood clotting)
Antiplatelet drugs like clopidogrel (potential bleeding risk alterations)
Thiazide diuretics (may increase calcium levels when combined with vitamin D3)
Calcium channel blockers (vitamin D3 may affect calcium balance)
Digoxin (vitamin D3 can increase calcium levels, potentially affecting heart rhythm)

Choosing Quality Supplements

Third-Party Testing

Look for products tested by NSF, USP, or ConsumerLab for purity and potency verification.

GMP Certified

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Transparent Labels

Avoid proprietary blends. Choose products that list exact amounts of each ingredient.

Bioavailable Forms

Some supplement forms are better absorbed than others. Research the optimal form for each nutrient.

Important Safety Information

This is not medical advice. The supplement information provided here is for educational purposes only. Always consult with a qualified healthcare provider before starting any supplement regimen.

Supplements can interact with medications, have contraindications for certain health conditions, and may not be appropriate for pregnant or nursing women. Quality and dosing can vary significantly between manufacturers.

The presence of a supplement on this page does not constitute an endorsement. We encourage you to research thoroughly and discuss with your healthcare team.