Calcium Alpha-Ketoglutarate (Ca-AKG)
Calcium Alpha-Ketoglutarate is a calcium salt of alpha-ketoglutaric acid, a naturally occurring compound involved in cellular energy production and metabolism. Research suggests it may support healthy aging by addressing multiple pathways including mitochondrial function and epigenetic processes, though human longevity studies are limited. Dietary supplements are not FDA-approved to diagnose, treat, cure, or prevent any disease. Consult your doctor before starting any supplement.
Key Takeaways
- Ca-AKG is a stable, bioavailable form of alpha-ketoglutarate that supports cellular energy production and may help address multiple aging pathways including mitochondrial function and epigenetics
- Clinical studies suggest doses of 1000-4500mg daily are safe and well-tolerated, with research showing potential benefits for biological age markers, muscle maintenance, and bone health
- Unlike many nutrients, AKG is not found in food sources, making supplementation the primary way to increase levels as they naturally decline with age
- Most beneficial for adults over 50 experiencing age-related decline in energy, recovery, or metabolic function, though human longevity studies remain limited
- Generally considered safe with few reported side effects, but the calcium content requires consideration for those with calcium-sensitive conditions
How to Take
Typical Dosage
Research doses range from 1-3g daily, though optimal dosing for longevity remains under investigation. Most clinical studies have used 1-2g daily for bone health and metabolic support.
When to Take
Take with meals to enhance absorption and reduce potential gastrointestinal upset
Why It Matters for Ages 50+
Adults over 50 experience declining levels of alpha-ketoglutarate, a key metabolite involved in cellular energy production and repair processes. Age-related changes in metabolism, bone health, and cellular function may benefit from Ca-AKG supplementation, though more human research is needed to confirm longevity benefits seen in animal studies.
What to Look For
- Look for calcium alpha-ketoglutarate (Ca-AKG) specifically, as this is the most stable and researched form compared to other AKG salts
- Choose products with third-party testing for purity and potency, as quality can vary significantly between manufacturers
- Verify the actual AKG content per serving, as some products may list total weight including the calcium carrier
- Select supplements stored in dark, cool conditions and check expiration dates, as AKG can degrade over time when exposed to heat and light
- Avoid products with unnecessary fillers, artificial colors, or additives that don't contribute to the supplement's effectiveness
Potential Interactions
Be aware of these potential interactions:
- Calcium channel blockers (amlodipine, nifedipine): May cause excessive blood pressure reduction due to calcium content
- Blood pressure medications: Calcium supplementation may reduce effectiveness of some antihypertensive drugs
- Thyroid medications (levothyroxine): Calcium can reduce thyroid hormone absorption - take 4+ hours apart
- Antibiotics (tetracyclines, quinolones): Calcium can significantly reduce antibiotic absorption
- Bisphosphonates (alendronate, risedronate): Calcium interferes with absorption - take several hours apart
- Iron supplements: Calcium can reduce iron absorption when taken together
- Thiazide diuretics: May increase calcium retention and risk of hypercalcemia
Who Should Avoid This Supplement
- Individuals with kidney stones or a history of calcium oxalate stones, as the calcium content may increase stone formation risk
- People with hypercalcemia or hyperparathyroidism, since additional calcium intake could worsen these conditions
- Patients with severe kidney disease or on dialysis should consult their nephrologist, as AKG affects nitrogen metabolism
- Pregnant or breastfeeding women, as safety data is insufficient for these populations
Recommended by Experts
“Part of Blueprint stack for anti-aging support”
Frequently Asked Questions
Clinical studies have used 1000-4500mg daily safely, with 1000mg being the most common effective dose. Take with food to improve absorption and reduce any potential stomach upset.
No, AKG is not found in significant amounts in foods. Your body produces it naturally as part of cellular energy metabolism, but levels decline with age, making supplementation the primary way to increase intake.
Some people report increased energy within weeks, but meaningful changes in biological age markers typically require 3-6 months of consistent use. Clinical studies showing biological age improvements used supplementation periods of several months.
Ca-AKG is generally well-tolerated with minimal side effects reported in clinical studies. Some people may experience mild digestive upset initially, which usually resolves by taking it with food.
Ca-AKG is bound to calcium, making it more stable and bioavailable than free AKG acid. The calcium also provides additional benefits for bone health, though it requires consideration for those monitoring calcium intake.
Ca-AKG can generally be combined with other longevity supplements like NMN or resveratrol, as they work through different pathways. However, space it away from iron supplements and certain medications to avoid absorption interference.