Metabolic

Sleep regulation and host genetics.

Advances in geneticsJanuary 8, 2024

View on PubMed DOI: 10.1016/bs.adgen.2024.02.002

AI Summary

This research chapter examines the genetic factors underlying sleep regulation, focusing on common sleep-related traits that affect general populations. The authors concentrate on sleep phenotypes that are highly prevalent and can be influenced by lifestyle modifications, including sleep quality, sleep duration, insomnia, restless leg syndrome, and daytime sleepiness. The study acknowledges that sleep regulation is a complex, multifactorial process involving genetic components. The researchers deliberately exclude rare sleep pathologies and conditions lacking sufficient scientific evidence for practical interventions. The chapter also recognizes the close relationship between sleep quality regulation and circadian rhythm control, though it treats circadian rhythm regulation as a separate topic requiring dedicated analysis. This approach suggests a focus on actionable sleep traits that individuals can potentially modify through lifestyle interventions, making it relevant for sleep optimization strategies.

Key Findings

Sleep regulation is identified as a multifactorial process involving genetic components
The study focuses on highly prevalent sleep phenotypes that can be modulated by lifestyle interventions
Key sleep traits examined include sleep quality, duration, insomnia, restless leg syndrome, and daytime sleepiness
Sleep quality regulation is intimately linked to circadian rhythm regulation

Abstract

Due to the multifactorial and complex nature of rest, we focus on phenotypes related to sleep. Sleep regulation is a multifactorial process. In this chapter, we focus on those phenotypes inherent to sleep that are highly prevalent in the population, and that can be modulated by lifestyle, such as sleep quality and duration, insomnia, restless leg syndrome and daytime sleepiness. We, therefore, leave in the background those phenotypes that constitute infrequent pathologies or for which the current level of scientific evidence does not favour the implementation of practical approaches of this type. Similarly, the regulation of sleep quality is intimately linked to the regulation of the circadian rhythm. Although this relationship is discussed in the sections that require it, the in-depth study of circadian rhythm regulation at the molecular level deserves a separate chapter, and this is how it is dealt with in this volume.

Authors

Adrián Odriozola, Adriana González, Jesús Álvarez-Herms, Francesc Corbi

Related Protocol

Blueprint Sleep Optimization

Study Details

Health Domain: Metabolic
Journal: Advances in genetics
Published: January 8, 2024
Authors: 4
Key Findings: 4

Metabolic
Calorie Restriction with or without Time-Restricted Eating in Weight Loss.
The New England journal of medicineApr 2022
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This 12-month randomized controlled trial examined whether time-restricted eating (8 AM-4 PM) combined with calorie restriction offers additional weight loss benefits compared to daily calorie restriction alone. The study assigned 139 patients with obesity to either time-restricted eating with calorie restriction (1200-1800 calories daily based on sex) or calorie restriction alone. The researchers found that time-restricted eating did not provide superior weight loss outcomes compared to standard calorie restriction. Both groups achieved meaningful weight loss, but the difference between approaches was not statistically significant. The study suggests that for individuals following the Blueprint Nutrition Protocol, the timing of food intake may be less critical than maintaining appropriate caloric intake for weight management. These findings indicate that while time-restricted eating can be an effective tool, it may not offer additional metabolic advantages beyond calorie control alone for weight loss in people with obesity.
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Blueprint Nutrition Protocol PubMed DOI
Metabolic
Do Brassica Vegetables Affect Thyroid Function?-A Comprehensive Systematic Review.
International journal of molecular sciencesApr 2024
AI Summary
This comprehensive systematic review examined the longstanding concern about whether brassica vegetables (including broccoli and broccoli sprouts) might negatively affect thyroid function. Researchers analyzed 123 studies including in vitro, animal, and human research to assess the impact of these vegetables and their compounds (glucosinolates and isothiocyanates) on thyroid health. The study investigated various thyroid markers including TSH, T3, T4 levels, iodine uptake, thyroid mass, and effects on thyroid cancer cells. The findings challenge previous assumptions about brassica vegetables being harmful to thyroid function. For individuals considering sulforaphane supplementation from broccoli sprouts, this research provides reassuring evidence that consuming these vegetables as part of a regular diet appears safe for thyroid health, particularly when adequate iodine intake is maintained. This is particularly relevant since concerns about thyroid effects have sometimes discouraged people from consuming these nutritionally valuable vegetables.
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Sulforaphane from Broccoli Sprouts PubMed DOI
Metabolic
Sulforaphane promotes diabetic wound healing by regulating macrophage efferocytosis and polarization.
International immunopharmacologyMar 2025
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This study investigated sulforaphane's potential for treating diabetic wounds, a common complication characterized by delayed healing and chronic inflammation. Researchers used diabetic mice and human cell cultures to examine how sulforaphane affects wound healing processes. The study found that topical application of sulforaphane accelerated wound healing in diabetic mice through specific immune system mechanisms. The compound enhanced macrophage efferocytosis (the process by which immune cells clear dead cells) and promoted M2 macrophage polarization, which reduces inflammation at wound sites. Mechanistically, sulforaphane activated the Nrf2 pathway, leading to increased production of heme oxygenase 1 and enhanced MERTK receptor function. In laboratory experiments using human immune cells, sulforaphane improved the ability of macrophages to clear dead cells and reduced inflammatory responses. These findings suggest sulforaphane from broccoli sprouts could potentially serve as a therapeutic agent for chronic diabetic wounds, though human clinical trials would be needed to confirm these benefits.
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Sulforaphane from Broccoli Sprouts PubMed DOI

Disclaimer: This research summary is for informational purposes only. Always consult the original study and qualified healthcare professionals before making any health decisions based on research findings.

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Key Findings

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