Sulforaphane from Broccoli Sprouts
Maximizing sulforaphane intake through broccoli sprouts for Nrf2 activation and detoxification.
Overview
Rhonda Patrick has highlighted sulforaphane as one of the most potent activators of the Nrf2 pathway, which controls over 200 genes involved in antioxidant defense and detoxification. Broccoli sprouts contain 10-100x more sulforaphane precursor than mature broccoli.
How to Follow This Protocol
Step 1: Source Broccoli Sprouts
Buy fresh broccoli sprouts or grow your own from seeds. Growing ensures freshness and is more economical. Seeds should be specifically for sprouting.
Step 2: Maximize Sulforaphane
Chew raw sprouts thoroughly or blend them. Heating destroys the myrosinase enzyme needed for sulforaphane conversion. If cooking, add mustard seed powder after to restore myrosinase.
Note: Frozen sprouts have 2x more sulforaphane when thawedStep 3: Daily Target
Consume roughly 100g (about 1 cup) of fresh broccoli sprouts daily. This provides approximately 40-60mg of sulforaphane equivalent.
Step 4: Alternative: Supplements
If sprouts aren't feasible, consider supplements like Avmacol or Prostaphane that contain stabilized sulforaphane or glucoraphanin with myrosinase.
Note: Supplements may be less potent than fresh sprouts
Benefits
- Powerful Nrf2 activation
- Enhanced detoxification pathways
- Potential anti-cancer properties
- May reduce inflammation
- Supports brain health
Risks & Considerations
- GI discomfort for some people
- Thyroid concerns with excessive raw cruciferous intake
- Taste can be challenging
Contraindications
Do not follow this protocol if any of the following apply:
- Thyroid conditions (consume in moderation)
- Those on blood thinners (vitamin K content)
