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BeginnerModerate EvidenceNutrition

Sulforaphane from Broccoli Sprouts

Maximizing sulforaphane intake through broccoli sprouts for Nrf2 activation and detoxification.

By Rhonda Patrick

Overview

Rhonda Patrick has highlighted sulforaphane as one of the most potent activators of the Nrf2 pathway, which controls over 200 genes involved in antioxidant defense and detoxification. Broccoli sprouts contain 10-100x more sulforaphane precursor than mature broccoli.

How to Follow This Protocol

  1. Step 1: Source Broccoli Sprouts

    Buy fresh broccoli sprouts or grow your own from seeds. Growing ensures freshness and is more economical. Seeds should be specifically for sprouting.

  2. Step 2: Maximize Sulforaphane

    Chew raw sprouts thoroughly or blend them. Heating destroys the myrosinase enzyme needed for sulforaphane conversion. If cooking, add mustard seed powder after to restore myrosinase.

    Note: Frozen sprouts have 2x more sulforaphane when thawed
  3. Step 3: Daily Target

    Consume roughly 100g (about 1 cup) of fresh broccoli sprouts daily. This provides approximately 40-60mg of sulforaphane equivalent.

  4. Step 4: Alternative: Supplements

    If sprouts aren't feasible, consider supplements like Avmacol or Prostaphane that contain stabilized sulforaphane or glucoraphanin with myrosinase.

    Note: Supplements may be less potent than fresh sprouts

Benefits

  • Powerful Nrf2 activation
  • Enhanced detoxification pathways
  • Potential anti-cancer properties
  • May reduce inflammation
  • Supports brain health

Risks & Considerations

  • GI discomfort for some people
  • Thyroid concerns with excessive raw cruciferous intake
  • Taste can be challenging

Contraindications

Do not follow this protocol if any of the following apply:

  • Thyroid conditions (consume in moderation)
  • Those on blood thinners (vitamin K content)

Medical Disclaimer

Disclaimer: This protocol is for educational purposes only and is not medical advice. Always consult with a qualified healthcare provider before starting any new health protocol, especially if you have existing health conditions or take medications.