Resveratrol Supplementation

Overview

Resveratrol is a polyphenol found in red wine and grapes that activates sirtuins, particularly SIRT1. David Sinclair's early research demonstrated resveratrol's ability to extend lifespan in various organisms. He takes it with a fat source to improve absorption.

How to Follow This Protocol

1. 1

   Step 1: Source Quality Resveratrol

   Choose trans-resveratrol from a reputable source. Look for products with verified purity and avoid those with fillers.

2. 2

   Step 2: Take with Fat

   Resveratrol is fat-soluble. Take it with a meal containing healthy fats (yogurt, olive oil, nuts) to improve absorption significantly.

   Note: Sinclair mixes his with yogurt in the morning
3. 3

   Step 3: Standard Dosing

   Take 500mg-1g of resveratrol daily. Sinclair reportedly takes 1g per day. Morning dosing is typically recommended.

4. 4

   Step 4: Combine with NMN

   For potential synergistic effects, consider taking resveratrol alongside NMN. Resveratrol activates sirtuins while NMN provides the NAD+ fuel they need.