NMN Supplementation Protocol

Overview

David Sinclair's research has highlighted the importance of NAD+ in cellular health and aging. NMN is a precursor to NAD+ and supplementation may help maintain NAD+ levels that naturally decline with age. Sinclair himself takes NMN daily as part of his longevity regimen.

How to Follow This Protocol

1. 1

   Step 1: Choose Quality NMN

   Select NMN from a reputable manufacturer with third-party testing. Look for >98% purity and proper storage conditions (some NMN is more stable refrigerated).

   Note: Sublingual or liposomal forms may have better absorption
2. 2

   Step 2: Start with Lower Dose

   Begin with 250mg per day for the first week to assess tolerance. Some people experience mild flushing or GI discomfort initially.

   1 week
3. 3

   Step 3: Increase to Target Dose

   Gradually increase to 500mg-1g daily. Sinclair reportedly takes 1g per day. Take in the morning to align with circadian rhythms.

   Note: Can be taken with or without food
4. 4

   Step 4: Monitor and Adjust

   Pay attention to energy levels, sleep quality, and overall wellbeing. Consider periodic blood tests for NAD+ levels if available.