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Supplement Catalog

Explore supplements commonly mentioned in longevity protocols. Each entry includes typical dosing, timing, and important interaction warnings.

  • Expert:David Sinclair

Supplements recommended by David Sinclair

  • Compounds

    Alpha-Lipoic Acid (ALA)

    Alpha-lipoic acid is a naturally occurring antioxidant compound that can cross the blood-brain barrier and may help reduce oxidative stress while supporting cellular energy production. Research suggests it may benefit blood sugar control, nerve function, and metabolic health, though more long-term studies are needed. Dietary supplements are not FDA-approved to diagnose, treat, cure, or prevent any disease. Consult your doctor before starting any supplement.

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  • Compounds

    CoQ10 (Ubiquinol)

    Coenzyme Q10 is a naturally occurring compound that plays a vital role in cellular energy production and acts as a powerful antioxidant. Ubiquinol is the active, reduced form of CoQ10 that is better absorbed than conventional CoQ10 supplements. It supports heart health, may help reduce migraine frequency, and can help counteract the natural decline in CoQ10 levels that occurs with aging.

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  • Compounds

    Fisetin

    Fisetin is a natural flavonoid compound found in strawberries and other fruits that has gained attention for its potential senolytic properties - the ability to help clear damaged 'senescent' cells from the body. Research suggests it may support cellular health and cognitive function, though human studies are still limited. Dietary supplements are not FDA-approved to diagnose, treat, cure, or prevent any disease. Consult your doctor before starting any supplement.

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  • Compounds

    NMN (Nicotinamide Mononucleotide)

    NMN is a naturally occurring compound that serves as a precursor to NAD+, a crucial molecule for cellular energy production and DNA repair. Research suggests it may support healthy aging by improving muscle function, insulin sensitivity, and cardiovascular health. While promising, human clinical trials are still limited and more research is needed to confirm long-term benefits.

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  • Fatty Acids

    Omega-3 Fish Oil (EPA/DHA)

    Omega-3 fish oil supplements provide essential fatty acids EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) that support cardiovascular health, reduce inflammation, and may benefit cognitive function. These supplements are derived from fatty fish and provide concentrated amounts of omega-3s that may be difficult to obtain from diet alone. Dietary supplements are not FDA-approved to diagnose, treat, cure, or prevent any disease. Consult your doctor before starting any supplement.

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  • Compounds

    Resveratrol

    Resveratrol is a polyphenolic compound naturally found in red wine, grapes, and berries that acts as a powerful antioxidant in the body. Research suggests it may support cardiovascular health, cognitive function, and healthy aging through its anti-inflammatory properties. Clinical studies have shown potential benefits for blood sugar control, weight management, and brain health, though more long-term research is needed.

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  • Compounds

    Spermidine

    Spermidine is a naturally occurring polyamine compound that plays a crucial role in cellular autophagy, the body's process of cleaning out damaged cells and regenerating healthier ones. As spermidine levels decline with age, supplementation may support longevity and cognitive function, though long-term human studies are still limited. Dietary supplements are not FDA-approved to diagnose, treat, cure, or prevent any disease. Consult your doctor before starting any supplement.

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  • Amino Acids

    Taurine

    Taurine is a sulfur-containing amino acid naturally produced by the body and found in high concentrations in the heart, brain, and muscles. It plays important roles in cardiovascular function, cellular hydration, and antioxidant defense. Dietary supplements are not FDA-approved to diagnose, treat, cure, or prevent any disease. Consult your doctor before starting any supplement.

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  • Compounds

    TMG (Trimethylglycine/Betaine)

    TMG (Trimethylglycine), also known as betaine, is a naturally occurring compound that supports methylation processes in the body and helps regulate cellular water balance. It can help reduce homocysteine levels and may support cardiovascular health, though it can also increase cholesterol levels in some individuals. Dietary supplements are not FDA-approved to diagnose, treat, cure, or prevent any disease. Consult your doctor before starting any supplement.

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  • Vitamins

    Vitamin D3 (Cholecalciferol)

    Vitamin D3 is the active form of vitamin D that supports bone health, immune function, and cardiovascular health by helping the body absorb calcium and phosphorus. Adults over 50 often have reduced vitamin D synthesis and may benefit from supplementation to maintain optimal blood levels. Dietary supplements are not FDA-approved to diagnose, treat, cure, or prevent any disease. Consult your doctor before starting any supplement.

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  • Vitamins

    Vitamin D3 + K2 (Cholecalciferol + Menaquinone)

    A synergistic combination of vitamin D3 and vitamin K2 that works together to optimize calcium metabolism in the body. Vitamin D3 enhances calcium absorption from the digestive tract, while vitamin K2 activates proteins that direct calcium to bones and teeth while preventing its accumulation in arteries. This partnership supports both bone health and cardiovascular protection.

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  • Vitamins

    Vitamin K2 (Menaquinone-7)

    Vitamin K2 is a fat-soluble vitamin that plays a crucial role in calcium metabolism, directing calcium to bones and teeth while preventing its accumulation in arteries and soft tissues. The MK-7 form has superior bioavailability and longer half-life compared to other forms of vitamin K. Dietary supplements are not FDA-approved to diagnose, treat, cure, or prevent any disease. Consult your doctor before starting any supplement.

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Choosing Quality Supplements

Third-Party Testing

Look for products tested by NSF, USP, or ConsumerLab for purity and potency verification.

GMP Certified

Good Manufacturing Practices certification ensures consistent quality and safety standards.

Transparent Labels

Avoid proprietary blends. Choose products that list exact amounts of each ingredient.

Bioavailable Forms

Some supplement forms are better absorbed than others. Research the optimal form for each nutrient.

Important Safety Information

This is not medical advice. The supplement information provided here is for educational purposes only. Always consult with a qualified healthcare provider before starting any supplement regimen.

Supplements can interact with medications, have contraindications for certain health conditions, and may not be appropriate for pregnant or nursing women. Quality and dosing can vary significantly between manufacturers.

The presence of a supplement on this page does not constitute an endorsement. We encourage you to research thoroughly and discuss with your healthcare team.