Supplement Catalog

Explore supplements commonly mentioned in longevity protocols. Each entry includes typical dosing, timing, and important interaction warnings.

Vitamin D3 + K2 (Cholecalciferol + Menaquinone)
A synergistic combination of vitamin D3 and vitamin K2 that works together to optimize calcium metabolism in the body. Vitamin D3 enhances calcium absorption from the digestive tract, while vitamin K2 activates proteins that direct calcium to bones and teeth while preventing its accumulation in arteries. This partnership supports both bone health and cardiovascular protection.
Typical Dosage
1000-4000 IU vitamin D3 with 45-180 mcg vitamin K2 daily (commonly 1000 IU D3 with 45-100 mcg K2)
When to Take
With meals containing fat for optimal absorption of both fat-soluble vitamins
Why for 50+
Adults over 50 experience decreased vitamin D production in the skin and reduced calcium absorption efficiency. Age-related changes in kidney function also affect vitamin D activation, while declining bone density increases the need for proper calcium utilization. The D3+K2 combination becomes particularly important as cardiovascular calcification risks increase with age.
Recommended by
DS
David Sinclair
Potential Interactions
Warfarin and other blood-thinning medications (vitamin K2 can affect blood clotting)
Antiplatelet drugs like clopidogrel (potential bleeding risk alterations)
Thiazide diuretics (may increase calcium levels when combined with vitamin D3)
Calcium channel blockers (vitamin D3 may affect calcium balance)
Digoxin (vitamin D3 can increase calcium levels, potentially affecting heart rhythm)

Vitamin D3 + K2 (Cholecalciferol + Menaquinone)
A synergistic combination of vitamin D3 and vitamin K2 that works together to optimize calcium metabolism in the body. Vitamin D3 enhances calcium absorption from the digestive tract, while vitamin K2 activates proteins that direct calcium to bones and teeth while preventing its accumulation in arteries. This partnership supports both bone health and cardiovascular protection.
Typical Dosage
1000-4000 IU vitamin D3 with 45-180 mcg vitamin K2 daily (commonly 1000 IU D3 with 45-100 mcg K2)
When to Take
With meals containing fat for optimal absorption of both fat-soluble vitamins
Why for 50+
Adults over 50 experience decreased vitamin D production in the skin and reduced calcium absorption efficiency. Age-related changes in kidney function also affect vitamin D activation, while declining bone density increases the need for proper calcium utilization. The D3+K2 combination becomes particularly important as cardiovascular calcification risks increase with age.
Recommended by
DS
David Sinclair
Potential Interactions
Warfarin and other blood-thinning medications (vitamin K2 can affect blood clotting)
Antiplatelet drugs like clopidogrel (potential bleeding risk alterations)
Thiazide diuretics (may increase calcium levels when combined with vitamin D3)
Calcium channel blockers (vitamin D3 may affect calcium balance)
Digoxin (vitamin D3 can increase calcium levels, potentially affecting heart rhythm)

Choosing Quality Supplements

Third-Party Testing

Look for products tested by NSF, USP, or ConsumerLab for purity and potency verification.

GMP Certified

Good Manufacturing Practices certification ensures consistent quality and safety standards.

Transparent Labels

Avoid proprietary blends. Choose products that list exact amounts of each ingredient.

Bioavailable Forms

Some supplement forms are better absorbed than others. Research the optimal form for each nutrient.

Important Safety Information

This is not medical advice. The supplement information provided here is for educational purposes only. Always consult with a qualified healthcare provider before starting any supplement regimen.

Supplements can interact with medications, have contraindications for certain health conditions, and may not be appropriate for pregnant or nursing women. Quality and dosing can vary significantly between manufacturers.

The presence of a supplement on this page does not constitute an endorsement. We encourage you to research thoroughly and discuss with your healthcare team.